Related Experiment Videos
Efficacy of progesterone antagonist RU486 (mifepristone) for pre-operative cervical dilatation during first trimester
F Durlot1, C Dubois, J Brunerie
1Service de Gynécologie Obstétrique, Hôpital Antoine Béclère, Clamart, France.
Human Reproduction (Oxford, England)
|July 1, 1988
Abstract:
A randomized double-blind study (RU486 versus placebo) was carried out in order to investigate whether a progesterone antagonist facilitated surgical abortion in the first trimester of pregnancy. The consistency of the cervix changed significantly after RU486 (P less than 0.02). We conclude that this effect may facilitate cervical dilatation, making first trimester abortion under local anaesthesia more comfortable and less dangerous.
Keywords:
Abortion, InducedBiologyCervical DilatationCervical EffectsCervixComparative StudiesDeveloped CountriesEndocrine SystemEuropeEvaluationFamily PlanningFertility Control, PostconceptionFranceGenitaliaGenitalia, FemaleHormone AntagonistsHormonesMediterranean CountriesPhysiologyResearch MethodologyRu-486StudiesTreatmentUrogenital SystemUterusVacuum AspirationWestern Europe