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Published on: October 26, 2020
Megalin: A bridge connecting kidney, the renin-angiotensin system, and atherosclerosis
Masayoshi Kukida1, Hisashi Sawada1, Alan Daugherty1
1Saha Cardiovascular Research Center and Department of Physiology, University of Kentucky, Lexington, KY, USA.
Abstract:
Megalin is a member of the low-density lipoprotein receptor superfamily. It has been recognized as an endocytic receptor for a large spectrum of ligands. As a consequence, megalin regulates homeostasis of many molecules and affects multiple physiological and pathophysiological functions. The renin-angiotensin system is a hormonal system. A number of studies have reported contributions of the renin-angiotensin system to atherosclerosis. There is evolving evidence that megalin is a regulator of the renin-angiotensin system, and contributes to atherosclerosis. This brief review provides contemporary insights into effects of megalin on renal functions, the renin-angiotensin system, and atherosclerosis.
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The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...

