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Nanotechnology in regenerative ophthalmology.

Fitsum Feleke Sahle1, Sangyoon Kim1, Kumar Kulldeep Niloy1

  • 1Department of Pharmaceutical Sciences, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA.

Advanced Drug Delivery Reviews
|November 11, 2019
PubMed
Summary

Nanotechnology enhances regenerative medicine for eye diseases by using nanomaterials as scaffolds and vectors for stem cells. This review covers applications in retina, cornea, and lens regeneration, advancing ocular tissue engineering.

Keywords:
Cell reprogrammingElectrospun nanofibersImmunomodulatorsNanoscaffoldsNanotopographyOcular regenerationSelf-assembled peptidesStem cells

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Area of Science:

  • Ophthalmology
  • Regenerative Medicine
  • Nanotechnology

Background:

  • Regenerative medicine offers hope for treating diseased, damaged, and aged tissues.
  • Nanotechnology is a key catalyst in advancing regenerative medicine.
  • Ocular diseases like AMD, glaucoma, and corneal trauma are targets for stem cell therapies.

Purpose of the Study:

  • To review nanomaterials for ocular tissue engineering and regeneration.
  • To discuss the current status and future of nanotechnology in ophthalmology.
  • To provide insights into nanotechnology for ocular tissue engineering and regeneration.

Main Methods:

  • Review of scientific literature on nanomaterials in ocular regeneration.
  • Analysis of stem cell applications with nanomaterials.
  • Discussion of nanotechnology's role in cell tracking and personalized ophthalmology.

Main Results:

  • Nanomaterials serve as scaffolds for stem cell adhesion, proliferation, and differentiation.
  • Nanomaterials act as vectors for genes, growth factors, and immunosuppressants.
  • Applications span retina, cornea, and lens regeneration.

Conclusions:

  • Nanotechnology is crucial for advancing ocular tissue engineering.
  • Future perspectives include cell tracking and personalized regenerative ophthalmology.
  • This field holds significant promise for restoring vision and ocular function.