Association of Subjective Memory Complaints with the Left Parahippocampal Amyloid Burden in Mild Cognitive Impairment
Il Han Choo1, Ari Chong2, Ji Yeon Chung3
1Department of Neuropsychiatry, Chosun University and Chosun University Hospital, Gwangju, Republic of Korea.
Background:
Subjective memory complaints (SMC) are a risk factor for Alzheimer's disease.
Objective:
We aimed to explore the association between SMC and regional amyloid-β (Aβ) deposition in mild cognitive impairment (MCI).
Methods:
Sixty-eight individuals with MCI were recruited. [18F]Florbetaben PET scans were performed. T1-weighted 3D volumes were also acquired for co-registration with PET and for defining the regions of interest (ROI). Two step exploratory partial correlation analyses between SMC and Aβ deposition were performed with covariates of age, sex, education, and depression. Furthermore, for the priori ROI that had the most significant partial correlation, we investigated the correlation between the SMC and regional Aβ burden using a multiple linear regression model controlling for depression, age, sex, and education.
Results:
Significant positive correlations between the SMC and Aβ burden was found in the medial temporal ROI (first step) and in the left parahippocampus ROI (second step). In the priori left parahippocampus, we found significant correlation between the SMC and Aβ burden (R2 = 0.473, p = 0.014).
Conclusions:
Our study suggested that the SMC was associated with amyloid accumulation, especially in the left parahippocampus, in individuals with MCI.
Insights
Subjective memory complaints (SMC) are linked to amyloid-beta (Aβ) buildup in the brain, particularly in the left parahippocampus, for individuals with mild cognitive impairment (MCI). This finding highlights a potential early indicator for Alzheimer's disease risk.
Area of Science:
- Neuroscience
- Biomedical Imaging
- Gerontology
Background:
- Subjective memory complaints (SMC) are recognized as a significant risk factor for developing Alzheimer's disease.
- Early detection and understanding of preclinical Alzheimer's disease are crucial for timely intervention.
Purpose of the Study:
- To investigate the association between subjective memory complaints (SMC) and regional amyloid-beta (Aβ) deposition in individuals diagnosed with mild cognitive impairment (MCI).
- To identify specific brain regions where Aβ accumulation correlates with memory complaints in MCI patients.
Main Methods:
- Recruited 68 individuals with MCI.
- Utilized [18F]Florbetaben Positron Emission Tomography (PET) scans to assess Aβ deposition.
- Performed exploratory partial correlation and multiple linear regression analyses, controlling for age, sex, education, and depression.
Main Results:
- A significant positive correlation was observed between SMC and Aβ burden in the medial temporal region and the left parahippocampus.
- Specifically, Aβ burden in the left parahippocampus showed a significant correlation with SMC (R² = 0.473, p = 0.014).
Conclusions:
- Subjective memory complaints are associated with increased amyloid accumulation in the brain among individuals with MCI.
- The left parahippocampus is a key region where this association is particularly evident, suggesting its potential role in early Alzheimer's disease pathology.
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