Hypertrophic callus formation leading to high-output cardiac failure in a patient with osteogenesis imperfecta

A 4-year old child with osteogenesis imperfecta developed high-output cardiac failure secondary to hypertrophic callus formation in four long bones. The association of hypertrophic callus formation with fracture and operative intervention is well known, but the role of infection in the aetiology of his condition is not well defined.