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Cognitive dysfunction and change in multiple sclerosis.

F R Halligan1, M Reznikoff, H P Friedman

  • 1Fordham University.

Journal of Clinical Psychology
|July 1, 1988
PubMed
Summary
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Cognitive function in multiple sclerosis (MS) patients shows mild decline in reasoning and memory with disease progression. Most patients maintain daily functioning, though some experience specific cognitive deficits.

Area of Science:

  • Neuropsychology
  • Neurology
  • Cognitive Science

Background:

  • Multiple sclerosis (MS) is a chronic neurological disease affecting cognitive functions.
  • Understanding the pattern and severity of cognitive decline in MS is crucial for patient management.

Purpose of the Study:

  • To assess neuropsychological variables in multiple sclerosis outpatients.
  • To examine the relationship between cognitive functioning and factors like age, disease duration, and disability.
  • To characterize the extent of cognitive deterioration in MS patients.

Main Methods:

  • Cross-sectional study involving 60 multiple sclerosis outpatients.
  • Utilized a test battery including WAIS subtests, Raven matrices, and memory tests (Wechsler Paired Associates, Benton Visual Retention).

Related Experiment Videos

  • Assessed cognitive variables in relation to age, disease duration, and disability degree.

    • Main Results:

    • Cognitive functioning in MS patients exhibits considerable variability.
    • A general, mild decline in abstract reasoning and memory correlates with disease progression.
    • Most deficits do not significantly impair occupational or social functioning.
    • 17% of patients showed specific cognitive function deterioration; 6.7% exhibited global deterioration.

    Conclusions:

    • Cognitive deficits in MS are generally mild and do not typically impede daily life.
    • Disease progression is associated with subtle declines in reasoning and memory.
    • A small subset of MS patients may experience more significant cognitive impairment.