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Interfibrillar shear behavior is altered in aging tendon fascicles.

Jared R Muench1, Darryl G Thelen1,2,3, Corinne R Henak4,5,6

  • 1Department of Mechanical Engineering, University of Wisconsin-Madison, 3031 Mechanical Engineering Building, 1513 University Avenue, Madison, WI, 53706, USA.

Biomechanics and Modeling in Mechanobiology
|November 11, 2019
PubMed
Summary

Aging alters tendon fascicle mechanics, reducing interfibrillar shear modulus. This age-related change in shear behavior contributes to increased injury risk in older tendons.

Keywords:
AgingFinite element modelingInterfibrillar matrixShear modulusTendon fascicle

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Area of Science:

  • Biomechanical Engineering
  • Gerontology
  • Musculoskeletal Research

Background:

  • Tendon elongation involves fascicle and fiber sliding.
  • Age-related matrix changes may affect tendon sliding and injury thresholds.

Purpose of the Study:

  • Investigate age-related effects on interfibrillar shear behavior in partial cut tendon fascicles.
  • Understand how aging impacts tendon mechanics and injury susceptibility.

Main Methods:

  • Cine microscopic imaging to track deformation in mature and aged rat tail tendon fascicles.
  • Finite element (FE) models coupled with experimental data to analyze tissue properties.
  • Comparison of intact and partial cut fascicles from mature (9 months) and aged (32 months) rats.

Main Results:

  • Aged tendons showed a 28% lower linear modulus and reduced toe region compared to mature tendons.
  • Partial cut fascicles exhibited a longitudinal shearing plane.
  • Aged fascicles displayed higher grip-to-grip strain at failure (11-20%) and more variable differential displacement.

Conclusions:

  • Aging reduces interfibrillar shear modulus, altering shear behavior in tendons.
  • Age-related changes in interfibrillar failure mechanisms contribute to increased tendon injury risk in older individuals.