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Related Experiment Videos

Targetoid hemosiderotic hemangioma.

D J Santa Cruz1, J Aronberg

  • 1Department of Pathology, Washington University School of Medicine, St. Louis, MO.

Journal of the American Academy of Dermatology
|September 1, 1988
PubMed
Summary
This summary is machine-generated.

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This study details a unique vascular lesion presenting as a targetoid skin lesion. Histological analysis reveals a complex proliferation with features that can mimic other conditions, though it appears self-limiting.

Area of Science:

  • Dermatopathology
  • Vascular Biology
  • Histology

Background:

  • A novel vascular lesion with distinct clinical and histological characteristics is presented.
  • Patients initially exhibit a small, single, annular, targetoid-appearing lesion.
  • Histological examination reveals a noncircumscribed vascular proliferation extending into subcutaneous tissue.

Purpose of the Study:

  • To characterize the clinical and histological features of this newly described vascular lesion.
  • To differentiate this lesion from other vascular tumors and conditions.
  • To understand the potential diagnostic challenges it presents.

Main Methods:

  • Clinical case description and presentation.
  • Histopathological analysis of biopsy specimens.

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  • Immunohistochemical staining for factor VIII-related antigen and Ulex europaeus 1 lectin.

    • Main Results:

    • Earliest findings include superficial ectatic dermal vascular lumina with papillary projections and epithelioid endothelial cells.
    • Deeper components show angular, lymphatic-like lumina around sweat glands, forming hemangiomatous nodules.
    • Extensive red cell extravasation, inflammation, fibrin thrombi, and hemosiderin deposition are observed in later stages.
    • Endothelial cells show weak positivity for factor VIII-related antigen and strong positivity for Ulex europaeus 1 lectin.

    Conclusions:

    • The lesion is persistent but self-limited, appearing clinically benign but histologically concerning.
    • Its nosologic designation is uncertain, sharing features with epithelioid hemangioma and progressive lymphangioma.
    • It poses significant differential diagnostic challenges, particularly with early Kaposi's sarcoma.