Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

1.1K
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
1.1K
Psychosurgery01:30

Psychosurgery

1.2K
Psychosurgery, the surgical alteration or permanent removal of brain tissue to alleviate severe psychological conditions, stands as one of the most radical and controversial treatments in the history of mental health care. Its development and application have evolved significantly, marked by dramatic shifts in scientific understanding and ethical perspectives.
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...
1.2K
Electroconvulsive Therapy01:30

Electroconvulsive Therapy

729
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
729
Seizures: Classification01:13

Seizures: Classification

1.3K
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Global Socioeconomic Context and Brain Ageing in Epilepsy: an ENIGMA-Epilepsy study.

medRxiv : the preprint server for health sciences·2026
Same author

High-frequency oscillations after acute hemorrhagic traumatic brain injury: insights into posttraumatic epilepsy development.

Epilepsia·2026
Same author

Etiology-specific trajectories of longitudinal functional connectivity and network topology in posttraumatic and mesial temporal lobe epileptogenesis.

Experimental neurology·2026
Same author

Developmental profile of physiological high-frequency oscillations in the human brain.

NeuroImage·2026
Same author

Short-term modulation of epileptic network with low-frequency thalamic stimulation.

Brain stimulation·2026
Same author

Multi-branch convolutional neural network and intracranial EEG high-frequency oscillations predict post-surgical seizure outcomes.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2026

Related Experiment Video

Updated: Jan 4, 2026

A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery
09:41

A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery

Published on: May 20, 2016

12.6K

Evolution of concepts in epilepsy surgery.

Jerome Engel1

  • 1Departments of Neurology, Neurobiology, and Psychiatry and Biobehavioral Sciences, and the Brain Research Institute, David Geffen School of Medicine, UCLA.

Epileptic Disorders : International Epilepsy Journal with Videotape
|November 12, 2019
PubMed
Summary

Epilepsy surgery has advanced significantly but remains underutilized. The main challenge is a treatment gap, with few eligible patients referred for timely surgical intervention, despite proven efficacy.

Keywords:
EEGILAEepilepsy surgeryhistoryneuroimagingneuropsychological testing

More Related Videos

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
09:32

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Published on: December 18, 2016

12.8K
Performing Behavioral Tasks in Subjects with Intracranial Electrodes
12:10

Performing Behavioral Tasks in Subjects with Intracranial Electrodes

Published on: October 2, 2014

11.8K

Related Experiment Videos

Last Updated: Jan 4, 2026

A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery
09:41

A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery

Published on: May 20, 2016

12.6K
Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients
09:32

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Published on: December 18, 2016

12.8K
Performing Behavioral Tasks in Subjects with Intracranial Electrodes
12:10

Performing Behavioral Tasks in Subjects with Intracranial Electrodes

Published on: October 2, 2014

11.8K

Area of Science:

  • Neurology
  • Neurosurgery
  • Epileptology

Background:

  • Epilepsy surgery evolved from a last resort in 1909 to a standard of care for drug-resistant focal epilepsy.
  • Early localization relied on semiology and structural lesions; EEG and neuroimaging later identified previously undetectable epileptogenic zones.

Observation:

  • Interest in epilepsy surgery surged mid-20th century with EEG and late 20th century with neuroimaging, leading to increased epilepsy centers and application in pediatric cases.
  • Modern techniques like laser ablation and neuromodulation expand surgical candidacy, with advanced presurgical evaluations enabling wider access.

Findings:

  • Despite proven safety and efficacy demonstrated by three randomized control trials, epilepsy surgery is under-utilized, with less than 1% of candidates referred.
  • Patients often wait 20 years post-epilepsy onset for surgery, risking irreversible disability.

Implications:

  • The primary barrier to maximizing epilepsy surgery's potential is a significant treatment gap, not a lack of treatment advancement.
  • Addressing referral delays and improving access to comprehensive epilepsy centers is crucial to ensure appropriate patients receive timely surgical intervention.