Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Appendicitis-I: Introduction

Appendicitis-I: Introduction

The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...

Appendicitis-II: Diagnostic Studies and Management

Appendicitis-II: Diagnostic Studies and Management

Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Directional Bias in Polyp Detection during Colonoscopy: A Prospective Observational Study.

Digestion·2026

Same author

ALBI Grade is a Determinant of Lenvatinib Pharmacokinetics, Efficacy, and Toxicities in Japanese Patients with Hepatocellular Carcinoma.

Clinical pharmacokinetics·2026

Same author

Recurrent Mutations in Protein Tyrosine Phosphatase Receptor Type Kappa (PTPRK) in Depressed-Type Colorectal Carcinomas.

Journal of biochemistry·2026

Same author

Delayed Duodenal Ulcer Perforation Following Esophageal Endoscopic Submucosal Dissection Complicated by Perforation: A Case Report.

DEN open·2026

Same author

Combined Assessment Findings of High Spleen Index and Fibrosis-4 Index Correlate With Fibrosis Progression in Fontan-Associated Liver Disease: A Retrospective Study.

Cureus·2025

Same author

Comparative Prognostic Roles of β-Catenin Expression and Tumor-Stroma Ratio in Pancreatic Cancer: Neoadjuvant Chemotherapy vs. Upfront Surgery.

Current oncology (Toronto, Ont.)·2025

Search research articles

Related Experiment Video

Updated: Jan 4, 2026

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Published on: August 24, 2019

[Primary appendiceal signet ring cell carcinoma:a case report].

Yoko Nakajima¹, Atsushi Kajiwara¹, Masashi Sakaki¹

¹Department of Medicine, Division of Gastroenterology, Showa University School of Medicine.

Nihon Shokakibyo Gakkai Zasshi = the Japanese Journal of Gastro-Enterology

|November 12, 2019

Summary

A rare case of signet ring cell carcinoma originating near the appendix caused intestinal obstruction and peritoneal dissemination in a 52-year-old woman. Despite chemotherapy, the disease progressed rapidly, leading to death within 12 months.

More Related Videos

Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model

Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model

Published on: April 18, 2025

Surgical Robot-Assisted Transanal Specimen Extraction Radical Sigmoidectomy Without an Auxiliary Abdominal Incision

Surgical Robot-Assisted Transanal Specimen Extraction Radical Sigmoidectomy Without an Auxiliary Abdominal Incision

Published on: June 13, 2025

Related Experiment Videos

Last Updated: Jan 4, 2026

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch

Published on: August 24, 2019

Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model

Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model

Published on: April 18, 2025

Surgical Robot-Assisted Transanal Specimen Extraction Radical Sigmoidectomy Without an Auxiliary Abdominal Incision

Surgical Robot-Assisted Transanal Specimen Extraction Radical Sigmoidectomy Without an Auxiliary Abdominal Incision

Published on: June 13, 2025

Area of Science:

Gastroenterology
Oncology
Pathology

Background:

Signet ring cell carcinoma is a rare subtype of adenocarcinoma.
Appendiceal tumors can present with vague abdominal symptoms.

Observation:

A 52-year-old woman presented with epigastralgia and abdominal discomfort.
Abdominal CT revealed intestinal obstruction and peritoneal dissemination.
Colonoscopy identified a submucosal tumor near the appendiceal orifice.

Findings:

Histological examination confirmed signet ring cell carcinoma.
The patient received modified FOLFOX chemotherapy.
Disease progression occurred after 8 courses of treatment.

Implications:

Signet ring cell carcinoma of the appendix can have a poor prognosis.
Early diagnosis and effective treatment strategies are crucial.
Further research into appendiceal signet ring cell carcinoma is warranted.