Protective effect of curcumin on fertility in cyclophosphamide exposed rats: Involvement of multiple pathways

This study assesses the effect of curcumin on cyclophosphamide (CPA)-induced functional alterations of the testicular, brain, and pituitary axis in common rodents, rats. Only CPA was given at 150 mg/kg body weight only on Day 1 or orally pre and posttreated with curcumin at 20 mg/kg body weight successively for 14 days. The outcomes showed that curcumin pre and posttreatments significantly affected the elevation of biomarkers of oxidative stress in CPA-induced rats, moreover, it increased nonenzymatic antioxidant levels in the epididymis, testes, and brain of the treated rats used in this study. In addition, followed by the preservation of histo-architectures of the epididymis, testes, and brain in the rats treated with CPA, curcumin helped in increasing the sperm quality and quantity and suppressing both the inflammatory indices and the activities of caspase-3, while pretreatment with curcumin gave a better result than posttreatment with curcumin. This may, therefore, represent a prospective adjuvant against CPA-induced spermatogenic deficits in humans. PRACTICAL APPLICATIONS: Jointly, through the antiapoptotic, antioxidant, and anti-inflammatory activities of curcumin, it instigated the toxicity of CPA-induced to be modulated along the testicular, brain, and pituitary axis in the rats. This may, therefore, represent a prospective therapeutic adjuvant against CPA-induced spermatogenic deficits in humans.