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Related Experiment Video

Updated: Jan 4, 2026

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An Atmosphere-Breathing Refillable Biphasic Device for Cell Replacement Therapy.

Duo An1, Long-Hai Wang1, Alexander Ulrich Ernst1

  • 1Biological and Environmental Engineering, Cornell University, Ithaca, NY, 14853, USA.

Advanced Materials (Deerfield Beach, Fla.)
|November 12, 2019
PubMed
Summary

A novel biphasic (BP) cell delivery device offers improved oxygen supply for cell replacement therapy. This transcutaneous device allows for non-surgical refilling, enhancing therapeutic cell survival and treatment feasibility.

Keywords:
3D printingbiphasiccell replacement therapyoxygen deliveryrefillable

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Endocrinology

Background:

  • Cell replacement therapy shows promise for endocrine disorders but faces challenges with cell survival due to low oxygen at transplantation sites.
  • Current cell delivery devices often require invasive procedures for replacement or refilling, limiting long-term therapeutic efficacy.
  • Limited oxygen supply and difficult device maintenance hinder the clinical translation of cell-based therapies.

Purpose of the Study:

  • To design and test a modular transcutaneous biphasic (BP) cell delivery device for enhanced cell survival and non-surgical maintenance.
  • To evaluate the oxygen supply capabilities and mass transfer performance of the BP device compared to conventional subcutaneous methods.
  • To assess the in vivo efficacy of the BP device for cell replacement therapy in an immunocompetent diabetes model and demonstrate non-surgical refilling.

Main Methods:

  • Development and testing of a modular transcutaneous biphasic (BP) cell delivery device with atmospheric oxygen access.
  • Mass transfer studies to compare oxygen supply performance against subcutaneous controls.
  • In vivo testing of islet encapsulation within the BP device in a rat-to-mouse xenograft model for diabetes correction.
  • Demonstration of non-surgical cell refilling in a canine model.

Main Results:

  • The BP device demonstrated significantly improved mass transfer and oxygen supply compared to subcutaneous controls.
  • Successful islet encapsulation in the BP device led to robust cell survival and sustained diabetes correction in a rodent xenograft model.
  • Non-surgical cell refilling of the device was successfully demonstrated in dogs, highlighting practical device management.

Conclusions:

  • The novel modular transcutaneous biphasic (BP) cell delivery device provides enhanced oxygenation and enables surgery-free cell refilling.
  • This innovative device significantly improves cell survival and therapeutic efficacy for cell replacement therapies, addressing key limitations of current approaches.
  • The BP device presents a feasible and practical solution for long-term cell-based treatments for endocrine disorders and hormone deficiencies.