Related Experiment Video

Updated: Jan 4, 2026

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
11:42

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Published on: April 7, 2017

9.8K

miR-922 regulates apoptosis, migration, and invasion by targeting SOCS1 in gastric cancer

Paerhati Shayimu1, Jing-Bin Wang2, Lin Liu1

  • 1Department of Gastrointestinal Surgery, The 3rd Affiliated Teaching Hospital of Xin Jiang Medical University (Affiliated Cancer Hospital), Urumqi, China.

The Kaohsiung Journal of Medical Sciences
|November 12, 2019
PubMed

Insights

MicroRNA-922 (miR-922) is overexpressed in gastric cancer (GC), correlating with lower patient survival. This study reveals miR-922 promotes GC cell growth and invasion by downregulating SOCS1, suggesting its diagnostic potential.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Gastric cancer (GC) is a leading cause of cancer mortality globally.
  • The role and mechanisms of microRNA-922 (miR-922) in GC remain largely unknown.
  • Previous research suggests miR-922 involvement in various diseases and tumors.

Purpose of the Study:

  • To investigate the expression and function of miR-922 in gastric cancer.
  • To elucidate the molecular mechanisms underlying miR-922's role in GC progression.
  • To assess the potential of miR-922 as a diagnostic marker for GC.

Main Methods:

  • Quantitative analysis of miR-922 expression in GC tissues and cells.
  • Assessment of patient survival rates based on miR-922 expression levels.
  • In vitro experiments using SGC7901 cells to evaluate the effects of miR-922 on apoptosis, proliferation, migration, and invasion.
  • Bioinformatic prediction and experimental validation of miR-922 targets, specifically SOCS1.
  • Analysis of SOCS1 mRNA levels in GC tissues.

Main Results:

  • miR-922 was significantly overexpressed in GC tissues and cells compared to adjacent tissues.
  • Higher miR-922 expression correlated with significantly lower patient survival rates.
  • Overexpression of miR-922 promoted SGC7901 cell proliferation, migration, and invasion while inhibiting apoptosis.
  • miR-922 directly targeted and downregulated the expression of Suppressors of Cytokine Signaling 1 (SOCS1).
  • SOCS1 mRNA levels were significantly reduced in GC tissues.

Conclusions:

  • miR-922 plays a crucial role in promoting gastric cancer progression by inhibiting apoptosis and enhancing proliferation, migration, and invasion.
  • The oncogenic function of miR-922 in GC is mediated through the downregulation of SOCS1.
  • miR-922 represents a potential diagnostic biomarker for gastric cancer.
Keywords:
carcinogenesisgastric cancermiR-922suppressors of cytokine signaling 1

More Related Videos

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment11:13

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment

Published on: June 9, 2023

2.2K
Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

8.0K

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.0K
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
3.1K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.6K
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.6K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
7.6K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.7K