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Related Concept Videos

Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

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Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular...
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Functions of the Lymphatic and Immune System01:28

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The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
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Development of the Lymphatic System01:15

Development of the Lymphatic System

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The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
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Fluid Connective Tissues: Blood and Lymph01:20

Fluid Connective Tissues: Blood and Lymph

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Blood and lymph are fluid connective tissues. They contain cells, also known as formed elements, circulating in a liquid extracellular matrix, the plasma. The formed elements are derived from hematopoietic stem cells in the bone marrow. Blood and lymph connect all vital parts and carry nutrients, oxygen, and other essential molecules like antibodies.
Blood
The blood flows through blood vessels— arteries, capillaries, and veins. Blood plasma is primarily made of proteins, solutes, and...
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Detailed Structure and Function of Lymph Nodes01:23

Detailed Structure and Function of Lymph Nodes

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Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
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Overview of the Vascular System01:20

Overview of the Vascular System

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The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
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Related Experiment Video

Updated: Jan 4, 2026

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice
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Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice

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Lymphatic vessels help mend broken hearts.

Catherine Pfefferli1, Anna Jaźwińska1

  • 1Department of Biology, University of Fribourg, Fribourg, Switzerland.

Elife
|November 12, 2019
PubMed
Summary

Lymphatic vessels are crucial for heart regeneration after injury in zebrafish. This study highlights their supportive role in cardiac repair processes.

Area of Science:

  • Cardiovascular Biology
  • Regenerative Medicine
  • Lymphatic System Research

Background:

  • Cardiac injury can lead to significant heart damage and impaired function.
  • The role of the lymphatic system in cardiac repair remains incompletely understood.

Purpose of the Study:

  • To investigate the involvement of lymphatic vessels in supporting heart regeneration following injury.
  • To elucidate the mechanisms by which lymphatic vessels contribute to cardiac recovery.

Main Methods:

  • Utilizing zebrafish as a model organism for cardiac injury and regeneration studies.
  • Employing advanced imaging techniques to visualize lymphatic vessel dynamics post-injury.
  • Genetic and pharmacological approaches to modulate lymphatic vessel function.
Keywords:
cardiac lymphaticscryoinjurydevelopmental biologyregenerationregenerative medicinerevascularizationstem cellszebrafish

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Main Results:

  • Zebrafish lymphatic vessels actively participate in the cardiac repair process after injury.
  • The presence and function of lymphatic vessels were found to be essential for effective heart regeneration.
  • Impaired lymphatic function led to reduced cardiac recovery.

Conclusions:

  • Lymphatic vessels play a vital supportive role in zebrafish heart regeneration.
  • Targeting the lymphatic system may offer novel therapeutic strategies for cardiac repair.