Spurious Low WBC Count from Sysmex XN3000: a Case Report
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Updated: Jan 4, 2026

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Evaluation of a Point-of-Care Testing Analyzer for Measuring Peripheral Blood Leukocytes
Published on: March 22, 2022
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Clinical Laboratory
|November 12, 2019
Abstract
Background:
We present a case of spurious low WBC count in a liver transplant patient. The patient is a 56-year-old man with liver cancer.
Methods:
His routine blood test revealed a decrease in WBC count: 0.03 x 109/L compared to 19.30 x 109/L before. The WBCs in the blood smear appeared higher than that reported by the XN without any aggregation. We diluted the blood sample to 1:7 with the DCL of the XN.
Results:
The diluted result matches the blood smear.
Conclusions:
Dilution mode may be a good choice when there is WNR and WDF discordance, and a smear must be reviewed.

