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Incidence and risk factors for recurrent cardiovascular disease in middle-eastern adults: a retrospective study
Romona D Govender1, Saif Al-Shamsi2, Elpidoforos S Soteriades3
1College of Medicine and Health Sciences, Department of Family Medicine, United Arab Emirates University, P.O. Box 17666, Al Ain, United Arab Emirates. govenderr@uaeu.ac.ae.
Insights
Recurrent cardiovascular events are common in the UAE. Older age, female sex, and diabetes mellitus significantly predict these events, highlighting the need for targeted preventive strategies in the United Arab Emirates population.
Area of Science:
- Cardiology
- Public Health
- Epidemiology
Background:
- Cardiovascular disease (CVD) poses a significant health burden globally, with high rates of recurrent events and mortality.
- The United Arab Emirates (UAE) exhibits one of the highest age-standardized death rates for CVD worldwide.
- Established CVD patients with risk factors face elevated risks of subsequent cardiovascular events and mortality.
Purpose of the Study:
- To determine the incidence rates of recurrent CVD events among UAE nationals.
- To identify key predictors of recurrent CVD events within this population.
Main Methods:
- An outpatient-based cohort study was conducted involving patients with a history of CVD.
- Follow-up extended for a median of 8.1 years, utilizing univariable and multivariable Cox proportional hazards regression models.
- Analysis focused on the association between major CVD risk factors and the risk of CVD recurrence.
Main Results:
- The study included 216 patients (167 males, 49 females) with a total of 1184 patient-years of follow-up.
- The overall incidence rate of recurrent CVD events was 92.1 per 1000 patient-years, with an 8-year cumulative incidence of 73.7%.
- Significant predictors identified were older age, female sex (1.96 times higher risk than males), and diabetes mellitus.
Conclusions:
- Older age, female sex, and diabetes mellitus are significant predictors of recurrent CVD events in UAE nationals.
- The high incidence rate underscores the need for enhanced preventive measures.
- Implementing international guidelines for CVD management may reduce morbidity and mortality in the UAE.
Background:
Individuals with established cardiovascular disease (CVD) and risk factors such as age, smoking, hypertension, and diabetes mellitus are at an increased risk of recurrent cardiovascular events and death. The incidence rate of recurrent CVD events varies between countries and populations. The United Arab Emirates (UAE) has one of the highest age-standardized death rates for CVD worldwide. The aim of our study was to estimate the incidence rates and determine the predictors of recurrent CVD events among UAE nationals.
Methods:
We investigated an outpatient-based cohort of patients with a history of CVD visiting Tawam Hospital between April 1, 2008 and December 31, 2008. They were followed-up until July 31, 2018. Univariable and multivariable Cox proportional hazards regression models were used to determine the association between major CVD risk factors and the risk of CVD recurrence.
Results:
A total of 216 patients (167 males, 49 females) with a history of CVD were included. They were followed for a median (interquartile range) of 8.1 (5.5-9.3) years, with a total of 1184 patient-years of follow-up. The overall incidence rate of recurrent CVD events was 92.1 per 1000 patient-years. The 8-year cumulative incidence was 73.7%. Age, female sex, and diabetes mellitus were significant predictors of recurrent CVD events, where females had a 1.96 times higher risk of recurrent CVD events than males.
Conclusion:
Significant predictors of recurrent CVD events are older age, female sex, and diabetes mellitus. The incidence rate of recurrent CVD events was 92.1 per 1000 patient-years. Preventive measures, based on international guidelines for CVD management, may improve CVD morbidity and mortality in the UAE population.
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