Related Experiment Video
Updated: Jan 4, 2026

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
Published on: April 7, 2023
Type-1 diabetes shapes working memory processing strategies
Francisco Javier Alvarado-Rodríguez1, Rebeca Romo-Vázquez2, Geisa Bearitz Gallardo-Moreno1
1Instituto de Neurociencias, CUCBA, Universidad de Guadalajara, 180 Francisco de Quevedo, 44130, Guadalajara, Jalisco, Mexico.
Background:
Type 1 diabetes (T1D) is a metabolic disorder characterized by recurrent hypo- and hyperglycemic episodes, whose clinical development has been associated with cognitive and working memory (WM) deficits.
Objective:
To contrast quantitative electroencephalography (qEEG) measures between young patients with T1D and healthy controls while performing a visuospatial WM task with two memory load levels and facial emotional stimuli.
Methods:
Four or five neutral or happy faces were sequentially and pseudo-randomly presented in different spatial locations, followed by subsequent sequences displaying the reversed spatial order or any other. Participants were instructed to discriminate between these two alternatives during EEG recording.
Results:
A significant increase in the absolute power of the delta and theta bands, distributed mainly over the frontal region was found during task execution, with a slight decrease of alpha band power in both groups but mainly in control individuals. However, these changes were more pronounced in the T1D patients, and reached their maximum level during the WM encoding phase, even on trials with the lower memory load. In contrast, changes seemed to occur more gradually in controls and results differed significantly only on the trials with the higher WM load.
Conclusions:
These results reflect adaptive WM-processing mechanisms in which cognitive strategies have evolved in T1D patients in order to meet task demands.
More Related Videos
Related Concept Videos
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Diabetes Mellitus: Type 2 and Gestational
Carbohydrate Metabolism
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Diabetes: Symptoms, Diagnosis, and Complications
Diabetes: Management and Pharmacotherapy
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...

