Lamprey vision: Photoreceptors and organization of the retina

The lamprey is an important non-model vertebrate because it is an agnathan or jawless vertebrate and belongs to the superclass cyclostomata, a group that split off from the rest of the vertebrates 500 million years ago. Investigation of the lamprey retina may therefore reveal attributes of visual function that were characteristic of even the most primitive vertebrates. The rod and cone photoreceptors are a striking example, because the biochemistry and physiology of phototransduction is remarkably similar between lamprey and the rest of the vertebrates, including mammals. The fundamental mechanism of light sensation seems therefore to have emerged very early in the evolution of vertebrates in the late Cambrian. Some other characteristics of the retina are also similar and may be very old, but other features such as the morphology of ganglion cells are rather different in lamprey and other vertebrates. Even these differences may provide new insight into the various mechanisms vertebrates use for visual detection.