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A Protocol for Functional Assessment of Whole-Protein Saturation Mutagenesis Libraries Utilizing High-Throughput Sequencing

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A Standard Numbering Scheme for Class C β-Lactamases.

Andrew R Mack^1,2, Melissa D Barnes^3,2, Magdalena A Taracila^3,2

¹Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, Ohio, USA.

Antimicrobial Agents and Chemotherapy

|November 13, 2019

Summary

This summary is machine-generated.

A standardized numbering scheme for AmpC beta-lactamases is proposed, addressing communication challenges in the field. This collaborative scheme considers sequence and structure, preserving key residue numbering for broader applications.

Keywords:

AmpC amino acid numbering beta-lactamases class C beta-lactamase conserved residue nomenclature structure-activity relationships

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Area of Science:

Biochemistry
Structural Biology
Microbiology

Background:

Class C (AmpC) beta-lactamases lack a standardized amino acid numbering scheme, unlike Classes A and B.
This absence complicates scientific communication and research collaboration in the field of antibiotic resistance.

Purpose of the Study:

To propose a standardized amino acid numbering scheme for AmpC beta-lactamases.
To facilitate clearer communication and enhance research in beta-lactamase studies.

Main Methods:

A collaborative approach integrating sequence and structural information was employed.
The scheme was designed to preserve the traditional numbering of key catalytic residues.

Main Results:

A novel, adaptable numbering scheme for AmpC beta-lactamases has been developed.
The scheme maintains consistent numbering for important residues like Ser64, Lys67, Tyr150, and Lys315.
A variation for genetic and epidemiological applications is included.

Conclusions:

The proposed numbering scheme standardizes AmpC beta-lactamase nomenclature.
This standardization will improve communication, research efficiency, and the study of antibiotic resistance mechanisms.