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KRAS regulation by small non-coding RNAs and SNARE proteins

Yonglu Che1,2, Zurab Siprashvili1,2, Joanna R Kovalski1,2

  • 1Program in Epithelial Biology, Stanford University, Stanford, CA, 94305, USA.

Nature Communications
|November 13, 2019
PubMed
Summary

Small nucleolar RNAs SNORD50A/B inhibit KRAS tumorigenic action by controlling its plasma membrane localization. These RNAs antagonize SNARE proteins, impacting KRAS signaling and offering a potential cancer therapy target.

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