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Updated: Jan 4, 2026

Surgical Correction for Pediatric Epiblepharon and Trichiasis
Published on: July 8, 2025
[Keratoplasty in children : Indications and results]
S J Lang1, D Böhringer2, T Reinhard2
1Klinik für Augenheilkunde, Medizinische Fakultät, Universitätsklinikum Freiburg, Kilianstr. 5, 79106, Freiburg, Deutschland. stefan.lang@uniklinik-freiburg.de.
Insights
Penetrating keratoplasty in children presents unique surgical challenges and requires careful consideration of pediatric-specific indications. Optimal timing is crucial to balance graft survival against the risk of amblyopia.
Area of Science:
- Ophthalmology
- Pediatric Surgery
- Corneal Surgery
Background:
- Penetrating keratoplasty (PK) in children involves unique challenges compared to adults.
- Pediatric indications, examination difficulties, and parental adherence impact surgical outcomes.
- Age is a risk factor, likely due to follow-up examination and compliance issues.
Purpose of the Study:
- To outline the specific challenges and considerations for performing penetrating keratoplasty in pediatric patients.
- To identify factors influencing graft survival and visual prognosis in children undergoing PK.
- To emphasize the critical role of surgical timing in pediatric corneal transplantation.
Main Methods:
- Review of pediatric-specific indications for penetrating keratoplasty.
- Analysis of factors affecting graft survival, including age and underlying ocular conditions.
- Discussion of the risk-benefit analysis concerning graft survival and amblyopia prevention.
Main Results:
- Favorable prognoses are seen in keratoconus and herpetic keratitis.
- Sclerocornea and Peters' anomaly often have limited visual and graft survival prognosis due to ocular malformations.
- Younger age is associated with increased risk, linked to examination and compliance challenges.
Conclusions:
- Successful pediatric penetrating keratoplasty requires addressing unique challenges in indications, examination, and adherence.
- Careful patient selection and management are vital, especially for conditions like sclerocornea and Peters' anomaly.
- The timing of surgery is paramount, balancing graft success with the critical risk of amblyopia development.
Abstract:
Penetrating keratoplasty in children is associated with very specific difficulties for the surgeon as well as for the patient and the parents. Special features are specific pediatric indications, which do not occur in adults, a more difficult examination and treatment adherence depending on the parents. Diseases with a favorable prognosis include keratoconus and herpetic keratitis. Especially sclerocornea and the Peters' anomaly often have a limited prognosis regarding vision and graft survival due to secondary malformations of the eye. In addition, younger age represents a risk factor. This is most likely due to the impaired examination during follow-up and reduced compliance. For successful penetrating keratoplasty in children the timing for the operation, in which the risk for the graft is weighed up against the risk for amblyopia, is crucial.

