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Tissue distribution of ethosuximide and clobazam in a seizure related fatality
A D Fraser1, A F Isner, S A Heifetz
1Toxicology Laboratory, Victoria General Hospital, Nova Scotia, Canada.
Journal of Forensic Sciences
|July 1, 1988
Abstract:
The case of a six-year-old male who died in a hospital while receiving several anticonvulsant drugs is described. Phenytoin, desmethyldiazepam, clobazam (an experimental 1,5 benzodiazepine), and desmethylclobazam were quantitated in serum, liver, and brain tissue by high performance liquid chromatography. Ethosuximide was quantitated by gas chromatography. To our knowledge, this is one of few reports describing tissue concentrations of ethosuximide collected at autopsy and the first report of clobazam/desmethylclobazam tissue distribution in man.