Therapeutic strategy for atherosclerosis based on bone-vascular axis hypothesis

Area of Science:

• Gerontology
• Vascular Biology
• Bone Biology

Background:

• The global population is aging, leading to a rising burden of atherosclerosis, a major cause of morbidity and mortality.
• Despite advancements in managing vascular risk factors, vascular events and atherosclerosis progression persist.
• Aging is associated with decreased bone mineral density, impacting hematopoietic stem cells and vascular integrity.

Purpose of the Study:

• To review recent advances in understanding the bone-vascular link.
• To explore novel therapeutic strategies for atherosclerosis by focusing on the bone-vascular interplay.
• To discuss new treatment targets for atherosclerosis.

Main Methods:

• Literature review of recent scientific advances.
• Analysis of the complex interplay between bone health and vascular integrity.
• Identification of potential therapeutic targets related to bone metabolism and inflammation.

Main Results:

• Aging significantly impacts bone health, affecting bone marrow microenvironments and hematopoietic stem cell function.
• Mineral dyshomeostasis and inflammation originating from bone contribute to atherosclerosis.
• The bone-vascular axis presents promising avenues for novel atherosclerosis therapies.

Conclusions:

• The intricate relationship between bone and vascular systems offers a new paradigm for treating atherosclerosis.
• Interventions targeting mineral homeostasis, bone marrow microenvironments, and inflammation show therapeutic potential.
• Further research into the bone-vascular link is crucial for developing effective atherosclerosis treatments.