Related Experiment Video
Updated: Jan 4, 2026
A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
A possible link between intracranial lipomas and localization-related relapses in multiple sclerosis
Thomas Mengesha1, Natalie Squires1, John Oas1
1Division of Neuroimmunology and Multiple Sclerosis and Departments of Neurology and Neuroscience, The Ohio State University Wexner Medical Center, Columbus, OH, United states; The James Comprehensive Cancer Hospital, Columbus, OH United States.
Abstract:
Intracranial lipomas are congenital malformations representing less than 0.5% of intracranial tumors. They are found incidentally and are asymptomatic in the majority of patients. Here we present three patients with Multiple sclerosis (MS) and intracranial lipomas (IL). The patients showed increased flares and burden of disabling and worsening MS symptoms with cognitive, neurovestibular dysfunction, and gait alterations associated with the localization of the Lipoma. The parenchyma near the Lipomas showed areas of demyelination and atrophy. We postulate that the location and content of the Lipomas may participate in the pathophysiology of MS symptoms in these patients. We conclude that in concurrent IL and MS, the lipomas localization may provoke incapacitating relapses.
