Related Experiment Video
Updated: Jan 4, 2026
09:44
Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
Published on: January 29, 2019
10.5K
Combination Radioimmunotherapy Strategies for Solid Tumors.
Javeria Zaheer1,2, Hyeongi Kim1, Yong-Jin Lee1
1Division of RI application, Korea Institute of Radiological and Medical Sciences, (KIRAMS), 75 Nowon-ro, Nowon-gu, Seoul 01812, Korea.
International Journal of Molecular Sciences
|November 14, 2019
Summary
Combination radioimmunotherapy (RIT) enhances cancer treatment by combining monoclonal antibodies with radionuclides. This approach overcomes limitations of RIT alone, improving drug delivery and efficacy for solid tumors.
Area of Science:
- Oncology
- Immunotherapy
- Radiochemistry
Background:
- Radioimmunotherapy (RIT) utilizes monoclonal antibodies (mAbs) linked to radionuclides for targeted cancer treatment.
- RIT alone shows limited efficacy against solid tumors due to delivery challenges.
- Combination RIT aims to improve mAb penetration and therapeutic outcomes.
Purpose of the Study:
- To review the principles and mechanisms of RIT for solid tumors.
- To discuss the limitations hindering RIT efficacy in solid tumors.
- To explore combination strategies for enhancing RIT effectiveness.
Main Methods:
- Literature review of RIT approaches and combination strategies.
- Analysis of mAb mechanisms and tumor targeting.
- Evaluation of factors affecting RIT in solid tumors.
Main Results:
- Monoclonal antibodies (mAbs) can selectively target tumor antigens.
- Barriers exist for mAb penetration into solid tumors, reducing RIT efficacy.
- Combination therapies, including drugs and other agents, can enhance mAb delivery and RIT effectiveness.
Conclusions:
- Combination RIT presents a promising strategy to overcome RIT limitations in solid tumors.
- Targeted delivery and enhanced efficacy are key benefits of combination RIT.
- Further research into combination RIT strategies is warranted for improved cancer treatment.
Related Concept Videos
01:27Tumor Immunotherapy
1.7K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
1.7K
02:49Cancer Therapies
9.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.7K
02:57Targeted Cancer Therapies
8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
8.6K
02:50Combination Therapies and Personalized Medicine
5.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.8K
01:30Cancer Vaccines
907
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
907
02:56Treatment Resistant Cancers
3.6K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.6K