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Pathogenic Effects of Impaired Retrieval between the Endoplasmic Reticulum and Golgi Complex
Hiroshi Kokubun1, Hisayo Jin1, Tomohiko Aoe2
1Department of Anesthesiology, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.
International Journal of Molecular Sciences
|November 14, 2019
Summary
The KDEL receptor regulates protein transport and cellular responses to endoplasmic reticulum stress. Dysfunction in this receptor is linked to various human diseases, highlighting its critical role in cell health.
Area of Science:
- Cellular Biology
- Molecular Biology
- Biochemistry
Background:
- Cellular functions like growth and secretion rely on proper protein folding and transport within the endoplasmic reticulum (ER).
- Cellular stress (e.g., ischemia, malnutrition, toxins) disrupts the ER folding environment, triggering the unfolded protein response (UPR).
- The KDEL receptor, activated by chaperones secreted from the ER, is crucial for cellular adaptation to stress.
Purpose of the Study:
- To review the role of the KDEL receptor in bidirectional transport between the ER and Golgi complex.
- To explore KDEL receptor-mediated signaling pathways.
- To discuss disease models and human conditions associated with KDEL receptor dysfunction.
Main Methods:
- Literature review of studies on KDEL receptor function.
- Analysis of experimental data on protein transport and signaling.
- Examination of disease models and clinical data related to KDEL receptor.
Main Results:
- The KDEL receptor is essential not only for retaining proteins in the ER but also for regulating transport between the ER and Golgi.
- Activated KDEL receptor signaling influences various cellular activities beyond protein retention.
- Dysfunction of the KDEL receptor is implicated in several pathological conditions.
Conclusions:
- The KDEL receptor plays a multifaceted role in cellular homeostasis, protein trafficking, and stress response.
- Understanding KDEL receptor-mediated pathways is vital for deciphering disease mechanisms.
- Targeting KDEL receptor pathways may offer therapeutic strategies for related diseases.
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