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Production and Detection of Reactive Oxygen Species ROS in Cancers
07:17

Production and Detection of Reactive Oxygen Species ROS in Cancers

Published on: November 21, 2011

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The Yin-Yang Regulation of Reactive Oxygen Species and MicroRNAs in Cancer

Kamesh R Babu1, Yvonne Tay1,2

  • 1Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore.

International Journal of Molecular Sciences
|November 14, 2019
PubMed

Insights

Reactive oxygen species (ROS) are crucial in cell signaling but drive cancer initiation and progression. MicroRNAs (miRNAs) regulate ROS, and ROS also control miRNA expression, revealing a complex interplay in cancer development.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Reactive oxygen species (ROS) are by-products of aerobic respiration and cellular reactions.
  • ROS are vital mediators of cellular signaling pathways, including proliferation, survival, apoptosis, and immune response.
  • Elevated ROS levels promote tumor initiation and cancer progression by inducing DNA damage and activating oncogenic pathways.

Purpose of the Study:

  • To review the role of ROS in cancer initiation and progression.
  • To summarize the regulatory crosstalk between ROS and microRNAs (miRNAs) in cancer.
  • To highlight how ROS influence miRNA expression and vice versa in carcinogenesis.

Main Methods:

  • Literature review of recent studies on ROS and miRNAs in cancer.
  • Analysis of the mechanisms by which ROS affect miRNA biogenesis, transcription, and epigenetic modifications.
  • Examination of how miRNAs regulate cellular ROS homeostasis.

Main Results:

  • ROS significantly contribute to cancer initiation and progression.
  • ROS modulate miRNA expression through various regulatory mechanisms.
  • miRNAs play a role in controlling cellular ROS levels by regulating ROS-producing and -eliminating proteins.

Conclusions:

  • The intricate relationship between ROS and miRNAs is a critical factor in cancer development.
  • Understanding this crosstalk offers potential therapeutic targets for cancer treatment.
  • Further research into ROS-miRNA interactions is essential for advancing cancer research.
Keywords:
ROSantioxidantscancermiRNAoxidative stress

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