Photoswitching off the Antiproliferative Activity of Combretastatin A-4 Analogues
Anton V Yadykov1, Alexander M Scherbakov2, Victoria V Trofimova3
1N. D. Zelinsky Institute of Organic Chemistry , RAS, 47, Leninsky prosp. , 119991 Moscow , Russian Federation.
Abstract:
The photostability and antiproliferative activity of combretastatin A-4 (CA-4) analogues against human epidermoid carcinoma cells A-431 were studied. For the first time, it was shown that UV or sunlight irradiation of furanone analogues of CA-4 results in a photorearrangement giving products with relatively low antiproliferative activity. The observed ability of this series CA-4 to the photodegradation can be used for the design of a new class of drug candidates with high selectivity to cancer cells.
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