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Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health Data
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Leisure activity and social integration mitigate the risk of dementia related to cardiometabolic diseases: A

Zhida Wang1,2, Anna Marseglia2, Ying Shang2

  • 1NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital and Tianjin Endocrinology Institute, Tianjin Medical University, Tianjin, China.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|November 14, 2019
PubMed

Insights

Comorbid cardiometabolic diseases (CMDs) significantly increase dementia risk. However, maintaining an active lifestyle, including social engagement, can mitigate this risk and delay dementia onset.

Area of Science:

  • Gerontology
  • Neurology
  • Public Health

Background:

  • Comorbid cardiometabolic diseases (CMDs), such as diabetes, heart disease, and stroke, are prevalent in older adults.
  • The impact of these combined conditions on dementia risk is not fully understood.

Purpose of the Study:

  • To investigate the association between cardiometabolic diseases and dementia risk.
  • To examine the potential protective effect of an active lifestyle on dementia development in individuals with CMDs.

Main Methods:

  • A 12-year prospective cohort study of 2648 dementia-free adults aged 60 years and older.
  • Active lifestyle defined by leisure activities and social network engagement.
  • Cox proportional hazards models were employed for statistical analysis.

Main Results:

  • Dementia risk increased with the number of CMDs: HR 1.41 for one, 2.38 for two, and 4.76 for three CMDs.
  • Participants with CMDs and an inactive lifestyle had a 3.36-fold increased dementia risk.
  • An active lifestyle reduced dementia risk by 3.5 years in individuals with CMDs.

Conclusions:

  • Comorbid CMDs are strongly associated with elevated dementia risk.
  • Leisure activities and social integration can significantly mitigate dementia risk in individuals with CMDs.
Abstract

Keywords:
Cardiometabolic diseasesDementiaLeisure activitiesPopulation-based cohort studySocial network

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