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Pancreatitis and hyperparathyroidism: Still a rare association!
Sandeep Thareja1, Manish Manrai2, Rajat Shukla3
1Consultant (Medicine) & Gastroenterologist, Base Hospital, Delhi Cantt, India.
Medical Journal, Armed Forces India
|November 14, 2019
Summary
Primary hyperparathyroidism (PHPT) is rarely linked to pancreatitis, but this study found a significant association. Investigating high calcium levels in pancreatitis patients is crucial for diagnosing PHPT.
Area of Science:
- Endocrinology
- Gastroenterology
- Oncology
Background:
- Primary hyperparathyroidism (PHPT) is an uncommon cause of pancreatitis.
- The relationship between PHPT and pancreatitis remains controversial.
- This study aimed to characterize pancreatic disease in PHPT patients.
Purpose of the Study:
- To investigate the association between primary hyperparathyroidism and pancreatitis.
- To characterize pancreatic manifestations in patients with PHPT.
- To determine the clinical significance of hypercalcemia in pancreatitis.
Main Methods:
- A retrospective study of 70 pancreatitis patients over one year.
- Patients with high calcium levels underwent Intact Parathyroid Hormone (iPTH) testing and Technetium 99m Sestamibi scintigraphy.
- Contrast-enhanced computed tomography (CECT) was used to assess pancreatitis severity.
Main Results:
- Five patients (9.4%) with pancreatitis were diagnosed with PHPT.
- Parathyroid adenoma was confirmed histologically in all cases.
- No recurrence of pancreatitis symptoms was reported during a 1-year follow-up.
Conclusions:
- A significant association exists between pancreatitis (acute and chronic) and hypercalcemia due to PHPT.
- Elevated calcium levels in pancreatitis patients warrant investigation for PHPT.
- Early diagnosis and management of PHPT can prevent pancreatitis recurrence.
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