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Related Concept Videos

Necrosis01:16

Necrosis

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Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
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A pneumothorax is a condition where air builds up in the space between the lung and the chest wall, causing the lung to collapse. This condition arises when air enters the space between the parietal and visceral pleura, disrupting the negative pressure essential for lung inflation. This can lead to a partial or complete collapse of the lung.
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Burn Injuries01:22

Burn Injuries

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Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
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Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

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Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
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Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

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Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
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Related Experiment Videos

Massive necrotizing fasciitis: a life threatening entity.

Ramon Vilallonga1,2,3, Alejandro Mazarro4, María Rita Rodríguez-Luna5

  • 1Endocrine Bariatric and Metabolic Unit, General Surgery Department, Universitary Hospital Vall d'Hebron, European Center of Excellence (EAC-BS), Barcelona, Spain.

Journal of Surgical Case Reports
|November 14, 2019
PubMed
Summary

Necrotizing fasciitis (NF), a severe soft tissue infection, requires prompt medical and surgical intervention to prevent sepsis. Early clinical suspicion and aggressive treatment, including surgery and antibiotics, are crucial for improving patient outcomes.

Related Experiment Videos

Area of Science:

  • Infectious Diseases
  • Surgical Pathology

Background:

  • Necrotizing fasciitis (NF) is a severe soft tissue infection often leading to sepsis.
  • Prompt medical and surgical treatment is essential for managing NF.

Observation:

  • Two postoperative cases of severe NF following oophorectomy and colorectal resection are presented.
  • Early symptoms can mimic less severe skin infections, necessitating high clinical suspicion.

Findings:

  • Surgical exploration confirms necrotizing infection and allows for resection.
  • Empirical broad-spectrum antibiotics should be initiated immediately.
  • NF has a high mortality rate, emphasizing the need for rapid, undelayed treatment.

Implications:

  • Expeditious diagnosis and treatment, including wide surgical resections and potential reconstructive surgery, are critical for patient survival.
  • Clinical vigilance is paramount in identifying NF, especially in postoperative patients.
  • Aggressive management strategies significantly impact patient outcomes in severe NF cases.