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Relationship between Ulcerative Colitis and Rheumatoid Arthritis: A Review
Mark G Attalla1, Sangeeta B Singh1, Raheela Khalid1
1Research, California Institute of Behavioral Neurosciences and Psychology, Fairfield, USA.
Cureus
|November 14, 2019
Summary
A link exists between ulcerative colitis (UC) and rheumatoid arthritis (RA). UC is a common complication of RA, with shared genetic factors and similar radiological changes, suggesting a significant relationship between these inflammatory diseases.
Area of Science:
- Gastroenterology and Rheumatology
- Immunology and Genetics
Background:
- Ulcerative colitis (UC) is a chronic inflammatory colonic disease.
- Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease affecting joints.
Purpose of the Study:
- To investigate the potential link between ulcerative colitis and rheumatoid arthritis.
- To understand how ulcerative colitis influences the progression of arthritis.
Main Methods:
- Systematic literature review following PRISMA guidelines.
- Data sourced from PubMed, PubMed Central (PMC), and Google Scholar.
- Inclusion of all study types published within the last 50 years, excluding non-English and animal studies.
Main Results:
- Arthritis is a frequent complication of UC, exhibiting radiological similarities to RA.
- Shared genetic markers (e.g., HLA-B27, IL-15, IgA) and therapeutic agents (e.g., omega-3) are identified in both conditions.
- Numerous studies indicate a high incidence of RA development in patients with UC over time.
Conclusions:
- A definitive relationship between ulcerative colitis and rheumatoid arthritis is established.
- The findings are relevant for clinicians, researchers, and patients managing these inflammatory conditions.
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