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Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
Published on: September 5, 2017
Miliary tuberculosis presenting as a choroidal mass and a tuberculosis screening review
Adam M Kase1, Claudia R Libertin2, Archana Roy3
1Mayo Clinic Florida Department of Internal Medicine, 4500 San Pablo Rd. South, Jacksonville, FL 32224, USA.
Abstract:
Anti-tumor necrosis factor alpha (anti-TNF) therapy is a standard of care in the management of many inflammatory conditions. However, anti-TNF pharmaceuticals increases the risk of reactivating tuberculosis making screening for latent tuberculosis infection (LTBI) a requirement prior to initiating therapy.
Case:
A middle-aged male from China with a past medical history of LTBI and Crohn's disease, previously on infliximab, presented to the United States for a second opinion on his abdominal pain. He also reported new onset visual changes. Ophthalmology evaluation revealed a 4 cm choroid mass of his left eye and a CT scan of the abdomen showed diffuse lymphadenopathy and lesions in his liver, spleen, and lung. He was admitted for treatment of miliary tuberculosis.
Discussion:
Immunocompromised patients are a unique population that brings challenges to LTBI testing.
Conclusion:
Clinicians should know the most up to date screening tools for LTBI and diagnostic workup for active tuberculosis infection.
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