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Updated: Jan 3, 2026

A General Method for Detecting Nitrosamide Formation in the In Vitro Metabolism of Nitrosamines by Cytochrome P450s
Published on: September 25, 2017
Diarylamine/diarylnitroxide cycle: quantum chemical and electrochemical estimation
Oleg A Levitskiy1, Vyacheslav V Sentyurin1, Tatiana V Magdesieva1
1Lomonosov Moscow State University, Chemistry Dept., Leninskie Gory 1/3, Moscow, 119991, Russia.
Abstract:
Possibility for diarylamine/diarylnitroxide cycling via electrochemical N-O bond formation/bond breaking processes was considered using quantum-chemical and electrochemical methods. It was shown that electrochemically reduced diarylnitroxides undergo fast N-O bond cleavage in the presence of oxophilic Li ions. The possible reaction scheme was suggested. In contrast, in the presence of Na+ salts, aminoxyl anions are stable and can be considered as possible anodic redox active material in energy storage systems utilizing Na+ ions migration. Direct oxygenation of diarylaminyl radicals with dioxygen yielding diarylnitroxide is not feasible; multiple competing routes involving the aromatic moiety are observed instead. The results obtained shed light on possibilities and limitations for functioning of nitroxide-based redox active electrode materials.
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