Related Experiment Video

Updated: Aug 14, 2026

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas
09:21

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Published on: September 13, 2019

Immunization with a syngeneic regressor tumor causes resorption in allo-pregnant mice

B Tartakovsky1, E Gorelik

  • 1Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel.

Journal of Reproductive Immunology
|July 1, 1988
PubMed

Insights

Mice immunized with tumors rejected fetuses from certain fathers but protected those from others. This suggests tumor antigen immunization can impact fetal survival based on paternal genetic background.

Area of Science:

  • Immunology
  • Reproductive Biology
  • Oncology

Background:

  • Maternal tolerance to semiallogeneic fetuses is crucial for successful pregnancy.
  • Tumor-associated antigens (TAAs) may share similarities with fetal antigens, potentially triggering immune responses.

Purpose of the Study:

  • To develop experimental models to disrupt maternal tolerance towards semiallogeneic fetuses.
  • To test the hypothesis that immunization against TAAs can induce immune responses against cross-reactive fetal antigens.

Main Methods:

  • C57BL/6J female mice were immunized with a syngeneic regressor tumor.
  • Immunized mice were mated with males of different genetic backgrounds (B6D2F1, DBA/2, CBA/J, C57BL/6J).
  • Embryo resorption rates were analyzed based on paternal origin.

Main Results:

  • A high proportion of embryos sired by B6D2F1 and DBA/2 males underwent resorption.
  • Embryos sired by CBA/J and C57BL/6J males were protected from resorption.
  • This indicates a differential immune response against fetuses based on paternal antigens.

Conclusions:

  • Tumor antigen immunization can break maternal-fetal tolerance in a genetically dependent manner.
  • The findings highlight the potential for immune-mediated fetal loss influenced by paternal antigen exposure.
  • This model system offers insights into immune regulation during pregnancy and potential therapeutic strategies.

More Related Videos

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice07:36

Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice

Published on: June 12, 2021

Syngeneic Mouse Orthotopic Allografts to Model Pancreatic Cancer06:20

Syngeneic Mouse Orthotopic Allografts to Model Pancreatic Cancer

Published on: October 4, 2022

Related Concept Videos

In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...