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Area of Science:

  • Electrochemistry
  • Biosensors
  • Materials Science

Background:

  • Accurate glucose monitoring is crucial for diabetes management.
  • Existing glucose sensors face challenges in stability and long-term performance.
  • Silicon-on-insulator (SOI) technology offers a robust platform for microelectronic devices.

Purpose of the Study:

  • To develop and evaluate a glucose oxidase (GOx) working electrode on an SOI wafer for electrochemical glucose sensing.
  • To investigate the sensing mechanism and performance characteristics of the developed SOI-GOx electrode.
  • To assess the stability and long-term viability of the SOI-GOx glucose sensor.

Main Methods:

  • Fabrication of a GOx working electrode on a hydrophilized SOI wafer using silanization with aminopropyltriethoxysilane and glutaraldehyde.
  • Electrochemical analysis, including cyclic voltammetry, to determine the sensing mechanism.
  • Evaluation of sensor performance, including linearity, stability, and response over time.

Main Results:

  • The SOI-GOx electrode exhibited a dominant hydrogen peroxide pathway, confirmed by oxygen-dependent responses.
  • A linear relationship was observed between cathodic peak height and glucose concentration up to 15 mM.
  • The electrode demonstrated good stability over 30 cycles and maintained functionality for distinguishing glucose concentrations even on day 133.

Conclusions:

  • The developed SOI-GOx working electrode is a promising candidate for implantable glucose sensors.
  • The sensor's stability and sensitivity indicate its potential for reliable, long-term glucose monitoring.
  • This work highlights the utility of SOI technology in advancing biosensor development.