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Related Experiment Videos

Systemic sclerosis and digital gangrene without scleroderma.

W G Barr1, J A Robinson

  • 1Department of Medicine, Loyola University Stritch School of Medicine, Maywood, IL.

The Journal of Rheumatology
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

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A man with digital gangrene, but no skin symptoms, was diagnosed with systemic sclerosis. Diagnostic tools identified this case, suggesting limitations in current disease classification.

Area of Science:

  • Rheumatology
  • Dermatology
  • Vascular Medicine

Background:

  • Systemic sclerosis is a multisystem connective tissue disease characterized by fibrosis, vascular abnormalities, and autoimmune dysfunction.
  • Diagnosis typically relies on specific clinical criteria, including skin involvement.

Observation:

  • A 67-year-old male presented with digital gangrene as the sole manifestation.
  • No other cutaneous signs suggestive of scleroderma were observed.

Findings:

  • Anticentromere antibody positivity.
  • Scleroderma pattern capillary abnormalities on nailfold capillaroscopy.
  • Histopathological evidence of digital artery disease.

Implications:

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  • This case highlights the potential for systemic sclerosis to present atypically, primarily with vascular complications.
  • Advanced diagnostic tools, such as serological markers and capillaroscopy, are crucial for identifying early or atypical cases.
  • Current classification criteria for systemic sclerosis may need refinement to encompass such presentations.