[PREECLAMPSIA: PATHOGENESIS AND MECHANISMS BASED THERAPEUTIC APPROACHES]

Area of Science:

• Obstetrics and Gynecology
• Nephrology
• Cardiology

Background:

• Preeclampsia affects 3-8% of pregnancies, causing significant maternal and fetal morbidity/mortality.
• It impacts multiple organs, including kidneys, heart, liver, brain, and lungs, primarily through endothelial injury.
• Pathogenesis involves angiogenic factor imbalances and coagulopathy, leading to widespread vascular damage.

Purpose of the Study:

• To review recent advancements in preeclampsia pathogenesis.
• To focus on novel diagnostic biomarkers and their therapeutic relevance.
• To highlight renal manifestations and the role of angiogenic balance in renal and cardiovascular outcomes.

Main Methods:

• Literature review of recent developments in preeclampsia research.
• Analysis of studies focusing on angiogenic factors and endothelial dysfunction.
• Examination of diagnostic biomarkers and therapeutic strategies.

Main Results:

• Endothelial injury is a common pathway for target organ damage in preeclampsia.
• Aberrations in angiogenic factors are implicated in the disease's clinical manifestations.
• Renal, hepatic, and neurologic dysfunctions stem from vascular damage.

Conclusions:

• Restoring angiogenic balance may improve renal and cardiovascular outcomes in preeclamptic women.
• Novel biomarkers are crucial for early diagnosis and targeted therapy.
• Further research into pathogenesis can lead to improved management of preeclampsia.