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The Second Gaddum Lecture: its origins and outcomes
1NHLI, Imperial College London, London, UK.
British Journal of Pharmacology
|November 14, 2019
Summary
John Vane's Second Gaddum Lecture, fifty years later, highlights foundational pharmacology experiments. Key findings led to cardiovascular advances like ACE inhibitors and low-dose aspirin, impacting modern medicine.
Area of Science:
- Pharmacology
- Cardiovascular Medicine
- Physiology
Background:
- The article revisits John Vane's Second Gaddum Lecture, delivered 50 years ago to the British Pharmacological Society.
- It connects the lecture's experiments to Sir John Gaddum's pioneering use of bioassay in pharmacology.
Purpose of the Study:
- To assess the origins and lasting impact of experiments presented in the Second Gaddum Lecture.
- To track the survival and influence of the lecture's findings over five decades.
Main Methods:
- Historical analysis of experimental origins linked to Gaddum's bioassay techniques.
- Retrospective assessment of experimental outcomes and their long-term scientific significance.
Main Results:
- The lecture's work initiated major cardiovascular advances: ACE inhibitors (anti-hypertensives) and low-dose aspirin (anti-thrombotic therapy).
- Identified a novel non-respiratory lung function involving endogenous vasoactive substrate metabolism.
- Recognized the endothelium as a critical, interactive component of blood vessels.
Conclusions:
- The research described in the Second Gaddum Lecture has profoundly shaped current pharmacology, physiology, and medicine.
- The lecture's legacy includes significant contributions to cardiovascular disease treatment and understanding of vascular biology.
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