Relationship between interleukin-10 polymorphisms and susceptibility to ischemic stroke: a Meta-analysis

Area of Science:

• Genetics and Molecular Biology
• Neurology
• Immunology

Background:

• Previous studies on the association between interleukin-10 (IL-10) gene polymorphisms and ischemic stroke (IS) have yielded conflicting results.
• Understanding the genetic predisposition to IS is crucial for developing targeted prevention and treatment strategies.
• The IL-10 cytokine plays a role in immune regulation and inflammation, potentially influencing IS pathogenesis.

Purpose of the Study:

• To conduct a comprehensive meta-analysis to clarify the relationship between IL-10 polymorphisms and IS risk.
• To investigate specific IL-10 single nucleotide polymorphisms (SNPs), including rs1800896, rs1800871, and rs1800872, in relation to IS.
• To pool data from existing studies to achieve greater statistical power and more reliable estimates of association.

Main Methods:

• Systematic literature search performed across major databases: PubMed, Web of Science, Embase, and CNKI.
• Inclusion of 17 studies comprising 3610 IS cases and 5171 controls.
• Calculation of pooled odds ratios (ORs) and 95% confidence intervals (CIs) using various genetic models (recessive, dominant, overdominant, allele) to assess associations.

Main Results:

• A significant association was found between the IL-10 rs1800896 polymorphism and IS susceptibility in the overall population (AA vs. GG+GA, recessive model: p=0.001, OR=1.42).
• Subgroup analyses revealed significant associations of rs1800896 with cerebral infarction under dominant (GG vs. GA+AA, p=0.02, OR=2.04), overdominant (GA vs. GG+AA, p=0.03, OR=0.50), and allele (G vs. A, p=0.01, OR=1.92) models.
• No significant associations were detected for IL-10 rs1800871 and rs1800872 polymorphisms with IS in the pooled analyses.

Conclusions:

• The IL-10 rs1800896 polymorphism is significantly associated with an increased susceptibility to ischemic stroke, particularly cerebral infarction.
• These findings contribute to understanding the genetic factors influencing IS risk.
• Further research may explore the functional mechanisms underlying the association between IL-10 rs1800896 and IS.