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Sarcopenia in COPD: a systematic review and meta-analysis.
Elizabeth Benz1,2,3, Katerina Trajanoska1,2,3, Lies Lahousse2,4
1Dept of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Summary
Sarcopenia, a loss of muscle mass and function, affects 21.6% of Chronic Obstructive Pulmonary Disease (COPD) patients. Standardized assessment is crucial for clinical practice and international comparisons.
Area of Science:
- Pulmonary Medicine
- Geriatrics
- Muscle Physiology
Background:
- Chronic Obstructive Pulmonary Disease (COPD) is linked to progressive muscle wasting and functional decline.
- Sarcopenia, characterized by low muscle mass and function, is an extrapulmonary manifestation in COPD.
- Current methods for estimating sarcopenia prevalence in COPD lack standardization.
Purpose of the Study:
- To systematically review and meta-analyze the prevalence of sarcopenia in COPD patients.
- To identify and consolidate existing data on sarcopenia in COPD across diverse settings.
Main Methods:
- Systematic review and meta-analysis of studies published up to January 17, 2019.
- Searched Embase, Medline, CINAHL, Web of Science, Scopus, and Google Scholar.
- Included 10 articles with 2565 COPD patients, excluding interventional studies and reviews.
Main Results:
- The overall prevalence of sarcopenia in COPD patients was 21.6% (95% CI 14.6-30.9%).
- Prevalence varied by setting: 8% in population-based, 21% in clinic-based studies, and 63% in nursing home residents.
- High heterogeneity (I²=94%) was observed across studies.
Conclusions:
- Sarcopenia is a common condition in COPD patients, with prevalence differing significantly by setting.
- Standardized diagnostic tests and cut-off points are essential for clinical assessment and global research.
- Further research is needed to establish consistent diagnostic criteria for sarcopenia in COPD.
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