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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
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Chemokine regulation of inflammation during respiratory syncytial virus infection

Rinat Nuriev1,2, Cecilia Johansson1

  • 1National Heart and Lung Institute, Imperial College London, London, UK.

F1000Research
|November 15, 2019
PubMed

Insights

Respiratory syncytial virus (RSV) causes severe lung infections, particularly in vulnerable groups. This review explores how chemokines regulate immune responses and inflammation during RSV infection.

Area of Science:

  • Immunology
  • Virology
  • Respiratory Medicine

Background:

  • Respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract infections and infant hospitalizations globally.
  • Immune responses are vital for controlling RSV but can lead to immunopathology if dysregulated.
  • Lung immunity initiation involves immune cell recruitment to the lungs.

Purpose of the Study:

  • To review recent advances in understanding RSV infection and disease.
  • To focus on the role of chemokines in regulating virus-induced inflammation in the lungs.

Main Methods:

  • Literature review of recent advances in RSV research.
  • Focus on the mechanisms of chemokine-mediated immune cell recruitment.

Main Results:

  • Chemokines are key regulators of inflammation during RSV infection.
  • Chemokines orchestrate the recruitment of various leukocytes to the lungs.
  • Dysregulated chemokine activity can contribute to RSV-associated immunopathology.

Conclusions:

  • Understanding chemokine function is crucial for managing RSV-induced lung inflammation.
  • Targeting chemokines may offer therapeutic strategies for severe RSV disease.

Keywords:
RSVchemokineslung inflammation

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