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Long-acting reversible contraception by effervescent microneedle patch.

Wei Li1, Jie Tang2, Richard N Terry1

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A novel effervescent microneedle patch offers reversible long-acting contraception. This innovative delivery system releases levonorgestrel for over a month, enhancing accessibility and avoiding sharps waste.

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Area of Science:

  • Reproductive Health
  • Biomaterials Science
  • Drug Delivery Systems

Background:

  • Long-acting reversible contraception (LARC) is crucial for managing unintended pregnancies.
  • Existing LARC methods can face challenges with administration, patient adherence, and biohazardous waste.
  • There is a need for innovative contraceptive delivery systems that are user-friendly and safe.

Purpose of the Study:

  • To develop and evaluate a novel effervescent microneedle patch for long-acting contraception.
  • To assess the drug release kinetics and in vivo performance of the contraceptive patch.
  • To gauge user interest and preference for this new contraceptive technology.

Main Methods:

  • Development of a microneedle patch formulated with biodegradable poly(lactic-co-glycolic) acid and levonorgestrel.
  • In vitro drug release studies to determine hormone elution over time.
  • In vivo studies in rats to assess sustained levonorgestrel levels and safety.
  • Human participant testing of a placebo microneedle patch for tolerability and user feedback.

Main Results:

  • The microneedle patch demonstrated slow release of levonorgestrel for over one month in vitro.
  • In vivo studies in rats showed sustained levonorgestrel concentrations above the contraceptive threshold for >1 month.
  • Placebo microneedle patches were well-tolerated in human participants.
  • Significant interest and preference for the microneedle patch contraceptive were observed in women across three continents.

Conclusions:

  • The effervescent microneedle patch is a promising, self-administered, long-acting contraceptive system.
  • This technology offers a potential solution for increasing access to contraception by eliminating sharps waste and simplifying administration.
  • Further clinical trials are warranted to confirm efficacy and safety in larger populations.