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Is phentolamine stable in solution with papaverine.
1Department of Surgery, University of Texas Medical School, Houston.
The Journal of Urology
|November 1, 1988
Summary
Phentolamine and papaverine mixtures are stable for at least 40 days, even when refrigerated or stored at room temperature. This finding supports the common use of these drugs in treating erectile dysfunction.
Area of Science:
- Pharmacology
- Analytical Chemistry
Background:
- Intracorporeal injections of phentolamine and papaverine are frequently used for erectile dysfunction diagnosis and treatment.
- Limited pharmacological data exists regarding the stability of these drug mixtures.
Purpose of the Study:
- To ascertain the stability of phentolamine mesylate in aqueous solution and when combined with papaverine.
Main Methods:
- High-performance liquid chromatography (HPLC)
- Gas chromatography with mass spectrometry (GC-MS) were employed to analyze drug stability.
Main Results:
- Phentolamine mesylate showed no degradation over a 40-day period.
- Stability was maintained whether the drug or its combination with papaverine was refrigerated or stored at room temperature.
Conclusions:
- Phentolamine is stable for at least 40 days when formulated in solution with papaverine.
- This stability supports the clinical use of phentolamine-papaverine mixtures for erectile dysfunction.