Related Experiment Video

Updated: Jan 3, 2026

Comet Assay to Quantify DNA Damage in FLT3 Mutant-expressing 32D Cells after Exposure to Type I and Type II FLT3 Inhibitors
04:36

Comet Assay to Quantify DNA Damage in FLT3 Mutant-expressing 32D Cells after Exposure to Type I and Type II FLT3 Inhibitors

Published on: October 17, 2025

789

Gab2 is Essential for Transformation by FLT3-ITD in Acute Myeloid Leukemia

Katharina Sies1,2, Corinna Spohr1,2,3,4, Albert Gründer2,5

  • 1Institute of Molecular Medicine and Cell Research (IMMZ), University of Freiburg, Freiburg, Germany.

Hemasphere
|November 15, 2019
PubMed
Abstract

No abstract available in PubMed .

More Related Videos

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
10:21

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells

Published on: February 21, 2018

10.4K
Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
11:15

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

24.9K

Related Experiment Videos

Last Updated: Jan 3, 2026

Comet Assay to Quantify DNA Damage in FLT3 Mutant-expressing 32D Cells after Exposure to Type I and Type II FLT3 Inhibitors
04:36

Comet Assay to Quantify DNA Damage in FLT3 Mutant-expressing 32D Cells after Exposure to Type I and Type II FLT3 Inhibitors

Published on: October 17, 2025

789
Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
10:21

Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells

Published on: February 21, 2018

10.4K
Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
11:15

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

24.9K

Related Concept Videos

TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

10.3K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
10.3K
Abnormal Proliferation02:23

Abnormal Proliferation

5.0K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.0K

Articles linked to this work by shared authors, journal, and citation graph.

A novel role for transcription factor NFE2 in redox regulation and chemotherapy resistance in acute myeloid leukemia.

Leukemia·2026

A Dsg3-specific pemphigus autoantibody induces formation of immature desmosomes associated with impaired adhesion.

Tissue barriers·2026

Metabolic disease variants rewire gene regulation through disruption of DNA G-quadruplex structures.

Genome biology·2026

First-in-human EphA2-targeting PET imaging with the bicyclic radiotracer [68Ga]Ga-BCY18469 in pancreatic cancer patients: biodistribution, dosimetry and initial findings.

European journal of nuclear medicine and molecular imaging·2026

MAGE-A4/MAGE-A8-targeted TCR-based bispecific T cell engager in recurrent and/or refractory solid tumors: a phase 1 trial.

Nature medicine·2026

Clinical Impact of Molecular Tumor Board Inclusion on Treatment Outcomes in Neuroendocrine Neoplasms.

Neuroendocrinology·2026

Targeted proteomics reveal histiocytosis-associated neurodegeneration signatures.

HemaSphere·2026

Mitochondrial DNA mutations are associated with impaired oxidative phosphorylation and enhanced imatinib response in chronic myeloid leukemia.

HemaSphere·2026

3D ex vivo platform for high-throughput immunotherapy screening in relapsed/refractory lymphoma patients.

HemaSphere·2026

AI for prognostic assessment of diffuse large B-cell lymphoma using H&E whole-slide images.

HemaSphere·2026

Machine learning provides individualized prediction of outcomes after first complete remission without allo-HSCT consolidation in adult acute myeloid leukemia-A HARMONY study.

HemaSphere·2026

Autologous stem cell transplantation versus consolidation chemotherapy as postremission treatment in newly diagnosed favorable- and intermediate-risk patients with AML: A comparative analysis of HOVON-SAKK-Nordic trials.

HemaSphere·2026

Morphometric and immunohistochemical reorganisation of the palatine tonsil in chronic tonsillitis and its response to combined ozone-ultrasound therapy.

Frontiers in surgery·2026

The Role and Mechanism of Endothelial Progenitor Cell-Derived Extracellular Vesicles in Vascular Repair of Ischemic Heart Disease.

Journal of cardiovascular translational research·2026

Alveolar epithelial depletion of βPAK-interacting exchange factor drives spontaneous pulmonary fibrosis by impairing stemness.

Signal transduction and targeted therapy·2026

Addressing translational barriers in intra-articular drug delivery for cartilage regeneration.

Journal of controlled release : official journal of the Controlled Release Society·2026

Enhancing Precision in Pelvic Tumor Reconstruction: Early Experience and Iterative Design of Custom 3D-Printed Implants.

Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews·2026

Reassembly of human kidney organoids after dissociation.

Nephron·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us