Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Visual Agnosia01:12

Visual Agnosia

828
Visual agnosia is a condition characterized by the inability to recognize visually presented objects despite having normal vision. For instance, a person with visual agnosia can describe the shape and color of an object but cannot identify or name it. This impairment does not affect their visual field, acuity, color vision, brightness discrimination, language, or memory. An example of this condition in a social setting is someone at a dinner party asking for "that silver thing with a round...
828
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

1.5K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Decomposition-based harmonization for quantitative PET imaging across scanners and radiotracers.

Medical physics·2026
Same author

Olfactory Valence-Processing Deficits and Aberrant Brain Network Connectivity Underlie Social Dysfunction in Shank3<sup>-/-</sup> ASD Model Mice.

Neuroscience bulletin·2026
Same author

Brain tau network derived biomarker improves the diagnostic accuracy of Alzheimer's disease.

Brain research bulletin·2026
Same author

A study on 18F-FDG PET/CT imaging assessment of the anti-aging efficacy of BMMSCs in the macaque brain.

Stem cells translational medicine·2026
Same author

Associations Between Early Functional Brain Network Topology and 6-Month Upper Limb Motor Outcomes in Stroke Patients.

Translational stroke research·2026
Same author

Stimulus-Dependent, Not Resting-State, Neural Dysfunction Underlies the Neurobiology of Delayed Ejaculation: A Task-Based fMRI Investigation.

Andrology·2026

Related Experiment Video

Updated: Jan 3, 2026

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease
06:23

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease

Published on: October 13, 2016

33.7K

Tau PET Distributional Pattern in AD Patients with Visuospatial Dysfunction.

Xi Sun1,2, Binbin Nie2,3,4, Shujun Zhao1

  • 1College of Physical Science and Technology, Zhengzhou University, Zhengzhou 450001, China.

Current Alzheimer Research
|November 15, 2019
PubMed
Summary
This summary is machine-generated.

Alzheimer's disease patients with visuospatial dysfunction show increased tau protein accumulation in the occipitoparietal cortex, posterior cingulate cortex, and precuneus. These brain regions are linked to visuospatial deficits in Alzheimer's disease (AD).

Keywords:
Alzheimer's diseaseAβ plaquesNFThyperphosphorylated tautau PETvisuospatial dysfunction.

More Related Videos

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
05:17

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Published on: April 18, 2025

730
Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
14:27

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

16.1K

Related Experiment Videos

Last Updated: Jan 3, 2026

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease
06:23

The 4 Mountains Test: A Short Test of Spatial Memory with High Sensitivity for the Diagnosis of Pre-dementia Alzheimer's Disease

Published on: October 13, 2016

33.7K
Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451
05:17

Hybrid PET/MRI Imaging of Alzheimer's Disease Based on 18F-AV-1451

Published on: April 18, 2025

730
Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
14:27

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

16.1K

Area of Science:

  • Neuroscience
  • Neurology
  • Medical Imaging

Background:

  • Visuospatial dysfunction is a key symptom in atypical Alzheimer's disease (AD), but its underlying neural mechanisms are not fully understood.
  • Intracellular hyperphosphorylated tau protein accumulation is a primary driver of neurodegeneration in AD.
  • Mapping tau distribution can reveal brain regions associated with specific cognitive impairments.

Purpose of the Study:

  • To investigate the neural correlates of visuospatial dysfunction in Alzheimer's disease by examining affected brain regions.
  • To identify specific brain areas with increased tau accumulation in AD patients exhibiting visuospatial deficits.

Main Methods:

  • Utilized 18F-AV-1451 tau positron emission tomography (PET) for imaging.
  • Employed voxel-wise two-sample t-tests to compare tau PET data.
  • Compared Alzheimer's disease patients with visuospatial dysfunction (VS-AD) against cognitively normal individuals.
  • Compared Alzheimer's disease patients without significant visuospatial dysfunction (non VS-AD) against cognitively normal individuals.

Main Results:

  • VS-AD patients exhibited increased tau accumulation in the occipitoparietal cortex, posterior cingulate cortex, precuneus, and inferior/medial temporal cortex.
  • Non VS-AD patients showed increased tau accumulation primarily in the inferior and medial temporal cortex.
  • Distinct patterns of tau deposition were observed between VS-AD and non VS-AD groups.

Conclusions:

  • The occipitoparietal cortex, posterior cingulate cortex, and precuneus are significantly affected by tau accumulation in VS-AD patients.
  • These specific brain regions are strongly associated with the visuospatial dysfunction observed in Alzheimer's disease.
  • Tau PET imaging can help elucidate the neuroanatomical basis of cognitive deficits in AD.