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Updated: Jan 3, 2026

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
16:24

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells

Published on: February 21, 2014

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MicroRNAs in breast cancer: Roles, functions, and mechanism of actions

Maryam Abolghasemi1,2, Sadra Samavarchi Tehrani3,4, Tooba Yousefi1,2

  • 1Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Iran.

Journal of Cellular Physiology
|November 15, 2019
PubMed

Insights

MicroRNAs (miRNAs) are key regulators in breast cancer development and progression. These small RNA molecules offer novel diagnostic and prognostic potential for this lethal malignancy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Breast cancer is a leading cause of death in women globally.
  • Gene expression alterations, particularly involving microRNAs (miRNAs), are implicated in breast cancer development and progression.
  • miRNAs play crucial roles in regulating key cellular processes relevant to tumorigenesis.

Purpose of the Study:

  • To review the multifaceted roles of microRNAs in breast cancer.
  • To elucidate the involvement of miRNAs in critical signaling pathways driving breast cancer.
  • To highlight the potential of miRNAs as diagnostic and prognostic biomarkers.

Main Methods:

  • Literature review of studies investigating microRNA function in breast cancer.
  • Analysis of miRNA involvement in major signaling pathways including TGF-β, Wnt, Notch, NF-κB, PI3K/Akt, and ERK/MAPK.
  • Synthesis of current data on miRNA-based diagnostics and prognostics.

Main Results:

  • miRNAs act as potent regulators, influencing both the initiation and advancement of breast cancer.
  • Specific miRNAs are shown to modulate critical oncogenic and tumor-suppressive signaling pathways.
  • Emerging evidence supports the utility of miRNAs in breast cancer patient stratification and monitoring.

Conclusions:

  • MicroRNAs are integral to breast cancer pathogenesis and progression.
  • Targeting miRNA pathways presents a promising therapeutic avenue.
  • miRNAs represent valuable biomarkers for improved breast cancer diagnosis and prognosis.
Keywords:
biomarkercancerdiagnosismicroRNAsprognosissignal pathway

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