Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Infertility in Males01:23

Infertility in Males

497
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
497
Sperm Structure and Semen Composition01:22

Sperm Structure and Semen Composition

9.6K
During ejaculation, males release around 2-5 milliliters of semen, which is a complex mixture of mature sperm and various fluids produced by accessory glands. The mature sperm cells measure approximately 60 micrometers in length and consist of a head, neck, midpiece, and tail. The head is flattened and tapered, measuring about 4 to 5 micrometers in length. It contains a nucleus with condensed chromosomes and an acrosome, a cap-like structure filled with enzymes essential for penetrating the...
9.6K
Infertility in Females01:28

Infertility in Females

3.6K
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
3.6K
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

3.9K
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
3.9K
Sperm Transport01:15

Sperm Transport

2.9K
The journey of sperm from its origin to the point of ejaculation begins within the seminiferous tubules of the testis. Here, Sertoli cells produce fluid that propels non-motile sperm through a series of conduits, starting with the straight tubules leading to the rete testis. This interconnected network of tubules acts as the initial pathway for sperm, guiding them into the efferent ductules and then into the epididymis for maturation.
The maturation phase occurs in the epididymis, where sperm...
2.9K
Spermatogenesis01:41

Spermatogenesis

120.9K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
120.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Personalized Management of Non-Obstructive Azoospermia: Current Evidence, Clinical Strategies, and Future Directions.

The world journal of men's health·2026
Same author

Emerging Diagnosis and Treatment of Male Infertility: Hope versus Reality.

The world journal of men's health·2026
Same author

Treating Erectile Dysfunction in Phosphodiesterase 5 Inhibitors Failures - Established Therapies and Newer Options.

The world journal of men's health·2026
Same author

The Impact of Leukemia Inhibitory Factor on <i>Sirtuin1</i>, <i>Ilt-4</i>, and Related microRNAs Expression in a Mouse Model of Recurrent Pregnancy Loss.

Reproductive medicine and biology·2026
Same author

Re-Imagining Male Infertility Guidelines Through the Global Andrology Forum.

The world journal of men's health·2026
Same author

Closing the Gap in Erectile Dysfunction Evaluation: Practical Insights for the Frontline Urologist.

The world journal of men's health·2026

Related Experiment Video

Updated: Jan 3, 2026

Vessel-Sparing Microsurgical Longitudinal Intussusception Vasoepididymostomy to Treat Epididymal Obstructive Azoospermia
06:28

Vessel-Sparing Microsurgical Longitudinal Intussusception Vasoepididymostomy to Treat Epididymal Obstructive Azoospermia

Published on: May 27, 2022

4.2K

Globozoospermia syndrome: An update.

Farzaneh Fesahat1, Ralf Henkel2,3, Ashok Agarwal3

  • 1Reproductive Immunology Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Andrologia
|November 15, 2019
PubMed
Summary
This summary is machine-generated.

Globozoospermia, a rare sperm defect, causes infertility and poor outcomes with conventional intracytoplasmic sperm injection (ICSI). This review explores globozoospermia characteristics, genetics, and advanced assisted reproduction technology (ART) treatments.

Keywords:
DNA fragmentationglobozoospermiahumanintracytoplasmic sperm injectionmorphologyspermatozoa

More Related Videos

Clinical Application of 24 G Cannula Needle and 3-0 Polypropylene Suture in Vas Deferens Exploration
07:21

Clinical Application of 24 G Cannula Needle and 3-0 Polypropylene Suture in Vas Deferens Exploration

Published on: February 10, 2023

3.0K
Author Spotlight: A Simple and Cost-Effective Method for Leukocyte Analysis in Semen
04:36

Author Spotlight: A Simple and Cost-Effective Method for Leukocyte Analysis in Semen

Published on: January 19, 2024

5.2K

Related Experiment Videos

Last Updated: Jan 3, 2026

Vessel-Sparing Microsurgical Longitudinal Intussusception Vasoepididymostomy to Treat Epididymal Obstructive Azoospermia
06:28

Vessel-Sparing Microsurgical Longitudinal Intussusception Vasoepididymostomy to Treat Epididymal Obstructive Azoospermia

Published on: May 27, 2022

4.2K
Clinical Application of 24 G Cannula Needle and 3-0 Polypropylene Suture in Vas Deferens Exploration
07:21

Clinical Application of 24 G Cannula Needle and 3-0 Polypropylene Suture in Vas Deferens Exploration

Published on: February 10, 2023

3.0K
Author Spotlight: A Simple and Cost-Effective Method for Leukocyte Analysis in Semen
04:36

Author Spotlight: A Simple and Cost-Effective Method for Leukocyte Analysis in Semen

Published on: January 19, 2024

5.2K

Area of Science:

  • Reproductive Biology
  • Human Genetics
  • Andrology

Background:

  • Male infertility is a significant concern, with rare genetic disorders like globozoospermia contributing to reduced fertility.
  • Globozoospermia is characterized by round-headed sperm lacking an acrosome, often linked to cytoskeleton defects.
  • Conventional assisted reproduction technology (ART) methods, including intracytoplasmic sperm injection (ICSI), show limited success in treating globozoospermia.

Purpose of the Study:

  • To review the key characteristics of globozoospermia, including sperm parameters, DNA integrity, and genetic factors.
  • To examine the current understanding of fertilization potential in globozoospermia patients.
  • To explore advanced treatment strategies and assisted reproduction technology (ART) for managing globozoospermia.

Main Methods:

  • Literature review of recent studies on globozoospermia.
  • Analysis of sperm parameters, DNA fragmentation (SDF), and chromatin integrity.
  • Evaluation of genetic findings and their correlation with globozoospermia phenotypes.
  • Assessment of current and emerging ART techniques for globozoospermia treatment.

Main Results:

  • Globozoospermia is associated with specific sperm morphology defects and compromised DNA/chromatin integrity.
  • Sperm DNA fragmentation (SDF) levels in globozoospermia patients require careful consideration for ART.
  • Genetic factors play a crucial role in the etiology and manifestation of globozoospermia.
  • Conventional ICSI outcomes are often suboptimal, necessitating alternative approaches.

Conclusions:

  • Effective management of globozoospermia requires a comprehensive understanding of its multifaceted characteristics.
  • Advanced ART techniques and personalized treatment strategies are essential for improving fertility outcomes in patients with globozoospermia.
  • Further research into the genetic basis and novel therapeutic interventions for globozoospermia is warranted.