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Studying RNA Interactors of Protein Kinase RNA-Activated during the Mammalian Cell Cycle
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Studying RNA Interactors of Protein Kinase RNA-Activated during the Mammalian Cell Cycle

Published on: March 5, 2019

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The RNA degradation pathway is involved in PPARα-modulated anti-oral tumorigenesis

Nai-Wen Chang1, Yi-Ping Huang2

  • 1Department of Biochemistry, College of Medicine, China Medical University, Taichung 404, Taiwan.

Biomedicine
|November 15, 2019
PubMed
Abstract

Insights

Activating peroxisome proliferator-activated receptor alpha (PPARα) reprograms oral tumor metabolism. Upregulating the RNA degradation pathway via PPARα activation presents a novel therapeutic strategy for oral cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Peroxisome proliferator-activated receptor alpha (PPARα) activation influences tumor metabolism.
  • PPARα shows potential in treating oral tumorigenesis.

Purpose of the Study:

  • To investigate functional pathways affected by PPARα activation in oral cancer.
  • To explore the anticancer mechanisms of PPARα in oral cancer cells.

Main Methods:

  • Utilized a pathway-based strategy for analysis.
  • Employed next-generation sequencing (NGS) and bioinformatic approaches.
  • Conducted Gene Ontology (GO) and KEGG enrichment analysis.

Main Results:

  • PPARα activation led to 3919 upregulated and 1060 downregulated genes.
  • Key affected pathways include proteasomal, mRNA surveillance, spliceosomal, RNA transport, and RNA degradation.
  • Identified 13 upregulated genes in the RNA degradation pathway, including exosome, TRAMP, CCR4-NOT, and Ski complex components.

Conclusions:

  • PPARα activation upregulates the RNA degradation pathway in oral cancer cells.
  • This suggests a potential new therapeutic strategy for oral cancer treatment.
Keywords:
Next-generation sequencingOral cancerPPARαRNA degradation pathway

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