[Metastatic cancer of unknown primary site]

The history, physical examination, radiographic and laboratory studies and histological diagnosis must be completely evaluated to search for the primary tumor. For diagnosis of cervical lymph node metastasis, not only whole body examination but also head and neck examination is important in which quadrascopy (nasopharyngeal, laryngeal and esophageal fiberoscopy and bronchoscopy) must be performed. If the localized lymph node metastasis of unknown primary site (TxNl-3MO); especially neck node, is presented, radiotherapy has an important role in cure. Patients with metastatic cancer of unknown primary site should be considered for early diagnosis and aggressive therapy.